评估SARS-CoV-2动物性传播溢出病毒的出现时间
Stéphane Samson1,2, Étienne Lord2, Vladimir Makarenkov1,3
1Department of Computer Sciences, Université du Québec à Montréal, Montréal, Canada.
PloS one
|April 4, 2024
概括
严重急性呼吸系统综合征冠状病毒 (SARS-CoV-2) 可能在2019年8月至10月期间传播给人类. 蝙蝠和松鼠冠状病毒通过基因转移在它的进化中发挥了作用.
科学领域:
- 病毒学 病毒学
- 进化生物学 进化生物学
- 基因组学就是基因组学.
背景情况:
- 了解冠状病毒的演变是防止未来流行病的关键.
- 目前,SARS-CoV-2的起源仍在调查中,其中包括蝙蝠和松鼠冠状病毒.
研究的目的:
- 分析冠状病毒的基因组数据,以确定SARS-CoV-2的进化时间表.
- 调查蝙蝠和松鼠冠状病毒在SARS-CoV-2进化中的作用.
主要方法:
- 对各种冠状病毒基因组数据的贝叶斯系遗传学分析.
- 严格和宽松的时钟进化模型的应用.
- 估计物种化,基因转移和重组事件时间.
主要成果:
- 估计在2019年8月至10月初之间发生的SARS-CoV-2动物性传播溢出.
- 2018年年中,证据表明S基因受体结合域的水平基因转移从蝙蝠到松鼠冠状病毒.
- 确定了一种特定的蝙蝠和松鼠冠状病毒类,与SARS-CoV-2密切相关.
结论:
- 该研究提供了SARS-CoV-2出现的精细时间表.
- 突出了蝙蝠到松鼠基因转移在SARS-CoV-2进化中的意义.
- 提供了关于大流行之前复杂的进化动态的见解.
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