传染性内心炎和抗血栓治疗治疗
Cristina Morelli1, Bianca Rocca1,2, Bruna Gigante3
1NeuroFarBa Department, University of Florence, Florence, Italy.
Cardiology
|April 4, 2024
概括
感染性内心炎 (IE) 患者面临高风险的栓塞和出血事件. 低剂量阿司匹林可以减少因IE住院后的死亡率,而不会增加出血风险.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 传染性内心炎 (IE) 发病率正在上升,原因是侵入性手术的增加和诊断的改善.
- IE涉及免疫血栓,经常导致栓塞性或出血性并发症.
- 在IE患者中管理抗血栓治疗是具有挑战性的,因为证据有限.
研究的目的:
- 审查IE中的栓塞和出血并发症.
- 检查IE患者的抗血栓治疗证据,有或没有先前的迹象.
主要方法:
- 在IE中对栓塞和出血并发症的文献综述.
- 对IE患者抗血栓治疗现有证据的分析.
主要成果:
- 血栓事件影响20-40%的IE患者,增加发病率和死亡率.
- 急性缺血性中风是最常见的神经系统并发症.
- 住院后低剂量阿司匹林可以减少90天的死亡率,而不会增加出血性中风.
结论:
- 抗血栓治疗在IE中缺血性中风预防中的作用缺乏可靠的试验数据.
- 脑内科患者有很高的出血风险;大脑内出血发生在5%左右.
- 由于知识差距,建议采用个性化抗血栓策略.
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