烟草使用对Zenker的分泌器切除术结果的影响
Lazaro R Peraza1, Katherine P Wallerius1, Andrew J Bowen2
1Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.
American journal of otolaryngology
|April 4, 2024
概括
烟草使用史不会影响Zenker的分泌器切除术结果. 这项研究发现,在手术后的吸烟者和非吸烟者之间,不良事件或复发率没有显著差异.
科学领域:
- 胃肠病学 胃肠病学
- 外科手术的结果
- 公共卫生 公共卫生
背景情况:
- 禅克分歧切除术 (ZD) 是一种治疗禅克分歧切除术的外科手术.
- 烟草使用是众所周知的各种不良健康结果的风险因素,但其对ZD结果的影响尚未得到充分证实.
研究的目的:
- 为了比较经过Zenker的分泌管切除术 (ZD) 的患者的临床结果,有或没有吸烟史.
- 调查烟草使用与不良事件之间的关联,以及ZD后的症状复发.
主要方法:
- 从2006年1月到2020年12月,在一个单一的三级医疗学术医院接受ZD的424名患者的回顾性评估.
- 收集的数据包括患者的人口统计学,分节性特征,不良事件 (出血,穿孔,再入院) 和症状复发的发生率.
- 统计分析包括无变量横截面分析和考克斯比例危险回归,根据年龄,性别和手术方法进行调整.
主要成果:
- 在424名患者中,有146名 (34.4%) 患者有吸烟史 (126名前吸烟者,20名活跃吸烟者).
- 在经过调整的分析中,在吸烟史和术后出血,穿孔,急诊室访问,计划外再接收或复发之间没有发现显著的关联.
- 非吸烟者中复发的中位时间为11.5年,前吸烟者为8.7年,活跃吸烟者为1.2年 (p=0.94).
结论:
- 烟草使用史 (活跃或以前) 与Zenker分泌管切除术后不良事件或复发率的增加无关.
- 虽然没有统计学意义,但趋势表明,与前和非吸烟者相比,活跃吸烟者复发的中位数时间较短.
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