细胞粘附分子在先前未服用药物和先前接受过药物的精神分裂症谱系障碍患者中
Kristian Varden Gjerde1, Christoffer Bartz-Johannessen2, Vidar Martin Steen3
1NKS Olaviken Gerontopsychiatric Hospital, Erdal, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway; NORMENT Centre of Excellence, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Schizophrenia research
|April 4, 2024
概括
精神分裂症患者表现出高水平的可溶性细胞粘附分子 (CAMs),表明潜在的内皮炎症. 这表明炎症在精神分裂症的发病过程中起着作用,即使在未使用过药物的个体中也是如此.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 内皮炎症与精神分裂症的发病有关.
- 细胞内皮细胞上的细胞粘附分子 (CAM) 可能调解白细胞结合和炎症因子迁移.
- 可溶性CAMs是内皮细胞激活的潜在生物标志物.
研究的目的:
- 为了比较精神分裂症患者与健康对照者的可溶性CAM水平.
- 为了研究特定的CAMs:ICAM-1,VCAM-1,MADCAM,JAM-A,以及N-CAD.
- 评估未使用过药物和先前服用过药物的精神分裂症患者之间的差异.
主要方法:
- 横截面研究比较了138名精神分裂症患者 (54名未使用过药物) 与317名对照.
- 对年龄,性别,吸烟和BMI进行调整的线性回归模型.
- 可溶性细胞间粘附分子 (ICAM) -1和血管粘附分子 (VCAM) -1水平的量化.
主要成果:
- 精神分裂症患者的ICAM-1和VCAM-1水平明显高于对照组 (p < 0.001).
- 以前接受过药物的患者比未服用药物的患者 (p = 0.042) 和对照组 (p < 0.001) 的ICAM-1水平更高.
- 与对照组相比,从未服用过药物的患者的VCAM-1升高 (p = 0.031).
结论:
- 精神分裂症患者的可溶性CAM水平升高,包括从未服用过药物的个人,表明内皮系统激活.
- 这些发现支持了在精神分裂症中炎症的作用.
- 可溶性CAMs可能作为精神分裂症炎症过程的生物标志物.
关键词:
细胞粘附分子的细胞粘附分子内皮内膜炎症的发生.神经炎症是一种神经炎症.非情感性精神病症的精神病.潘斯斯 (Panss) 是一个名为潘斯 (Panss) 的企业.精神分裂症 - 精神分裂症谱系障碍更多相关视频
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