青春期前暴露于多环芳与男孩早期青春期发育的发生有关:一项纵向研究
Yujie Wang1, Wenyi Wu1, Mercedes A Bravo2
1Research Center for Environment and Human Health, Research Center for Medicine and Social Development, School of Public Health, Chongqing Medical University, Chongqing 401331, PR China.
Journal of hazardous materials
|April 4, 2024
概括
在男孩中,多环芳 (PAH) 暴露可能导致更早的青春期. 这项研究发现了特定的PAH代谢物与阴毛,面部毛发和丸生长的早期发展之间的联系.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 多环芳 (PAH) 是环境污染物,与各种健康问题有关.
- 青春期的发展是一个由遗传和环境因素影响的关键时期.
- 了解环境对男性青春期的影响对于公共卫生至关重要.
研究的目的:
- 调查暴露于多环芳 (PAH) 与男孩青春期发育时间之间的关联.
- 为了确定可能影响青春期开始和进展的特定PAH代谢物.
主要方法:
- 来自中国重庆的695名男孩的队列在2015年12月至2021年6月的六个月间隔内对青春期发育进行了监测.
- 从675名男孩的尿液样本中分析了四种PAH代谢物:1-基烯 (1-OHPyr),2-基纳酸 (2-OHNap),2-基烯 (2-OHFlu) 和9-基烯 (9-OHPhe).
- 考克斯的比例危险回归模型被用来评估PAH代谢物水平和青春期计时指标之间的关系.
主要成果:
- 适度暴露于1-OHPyr与较早的丸发育有关 (HR=1.276).
- 适度暴露于2-OHNap与较早的丸和尾毛发发育相关 (HR=1.273和HR=1.355).
- 中度的2-OHFlu暴露与早期的阴毛发育有关 (HR=1.256),而高的9-OHP暴露与早期的第一次射精和面部毛发发育有关 (HR=1.333和HR=1.393).
结论:
- 青春期前暴露于特定的多环芳 (PAHs) 可能与男孩早期的青春期发生有关.
- 这些发现凸显了PAHs对男性生殖发育的潜在内分泌干扰作用.
- 需要进一步的研究来证实这些关联并阐明底层机制.
相关概念视频
Signs of Puberty
337
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
337
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Attention-Deficit/Hyperactivity Disorder
59
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
59
Mutagenicity and Carcinogenicity
1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Disorders of the Male Reproductive System
404
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
404


