相关实验视频

Updated: Jul 17, 2026

Protocol to Create Chronic Wounds in Diabetic Mice

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

硫化调节巨细胞两极分化和亡,以加速糖尿病皮肤伤口愈合

Ziying He¹, Yue Zhu¹, Haojie Ma¹

¹Department of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China.

International immunopharmacology

|April 4, 2024

概括

硫化 (H2S) 对于糖尿病人的伤口愈合至关重要. 这项研究表明,H2S治疗通过调节炎症,促进血管生长和减少细胞死亡来加速愈合.

科学领域:

生物化学生化学
病理生理学病理生理学
伤口治愈研究研究伤口治愈研究

背景情况:

硫化 (H2S) 是第三种气体传递物,在疾病病理生理学中至关重要.
囊氨酸γ-酶 (CSE) 是皮肤H2S生产的主要酶.
在糖尿病患者的皮肤伤口愈合中H2S的作用尚未完全理解.

研究的目的:

研究H2S在糖尿病患者皮肤伤口愈合中的作用和机制.
为了确定H2S是否可以成为糖尿病伤口的治疗策略.

主要方法:

检查了患有伤口的糖尿病患者的血H2S水平.
使用了CSE淘汰赛的糖尿病小鼠和缺乏叶黄素受体 (db/db) 的小鼠.
在小鼠模型中用硫化 (NaHS) 作为H2S供体.

主要成果:

在CSE淘汰赛糖尿病小鼠中,治疗延迟,输液减少,炎症/亡标志物发生变化.
在db/db小鼠中,NaHS治疗加速了伤口愈合.
H2S调节了巨细胞极化,亡和炎症反应.

结论:

H2S在加速糖尿病患者皮肤伤口愈合方面发挥着重要作用.
H2S 调节了巨细胞极化和亡途径.
H2S代表了糖尿病伤口治疗的有前途的治疗途径.

关键词:

糖尿病是一种糖尿病.硫化是一种硫化.巨细胞的两极分化尸体灭 (Necroptosis) 是一种死亡的过程.皮肤上的伤口.

更多相关视频

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

相关概念视频

Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...