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Updated: Jul 20, 2026

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无知是幸福:抑制蛋白质体应激感知可以改善直接的神经元转换

Larissa Traxler1, Oliver Borgogno1, Jerome Mertens1

  • 1Department of Neurosciences, University of California San Diego, La Jolla, CA, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.

Neuron
|April 4, 2024
PubMed
概括

直接将细胞转化为神经元可以帮助模拟疾病并开发疗法. 研究人员发现,展开的蛋白质反应 (UPR) 途径阻断了这一过程,但克服它可以改善神经元重编程.

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