婴儿微生物和代谢物表明儿童的神经发育障碍
Angelica P Ahrens1, Tuulia Hyötyläinen2, Joseph R Petrone1
1Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32603, USA.
Cell
|April 4, 2024
概括
早期生活因素如感染,抗生素和压力与神经发育障碍 (ND) 有关. 婴儿的微生物组和生物标志物可以预测未来的ND诊断,从而使早期干预成为可能.
科学领域:
- 神经科学
- 儿童医学
- 遗传学
背景情况:
- 神经发育障碍 (ND) 是一个重大的公共健康问题.
- 确定早期的风险因素对于及时干预和改善结果至关重要.
研究的目的:
- 研究生命早期因素与神经发育障碍 (ND) 诊断风险之间的关联.
- 探索婴儿生物标志物的作用,包括微生物组和代谢组,预测ND的发展.
主要方法:
- 一项前性纵向研究追踪了16440名瑞典儿童超过20年.
- 收集的数据包括有关感染,抗生素使用,压力,产前因素和家族病史的问卷.
- 评估的生物标志物:带血清代谢组/脂质组,HLA基因型,婴儿微生物组和便代谢组.
主要成果:
- 1,197名儿童患有ND,与一般ND和特定亚型 (智力障碍,言语障碍,多动症,自闭症) 发现了显著的关联.
- 微生物组变化和早期情绪/胃肠道问题与未来的ND诊断有关.
- 研究结果表明免疫失调,新陈代谢,压力,早期感染和抗生素暴露之间的相互作用.
结论:
- 早期生物标志物和风险因素汇聚在一起,为预测神经发育障碍提供了基础.
- 这项大规模的前性研究突出了早期疾病预测和干预策略的潜力.
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