炎症性抑郁症与选择性淋巴细胞低过有关
Gustav Söderberg Veibäck1, Linnea Malmgren2, Marie Asp3
1Unit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Sweden; Department of Gastroenterology and Nutrition, Department of Clinical Sciences Skåne University Hospital, Malmö, Sweden.
Journal of affective disorders
|April 4, 2024
概括
选择性淋巴细胞过综合征 (SGHS) 在难以治疗的抑郁症患者中更常见. 这表明SGHS可能是炎症抑郁症的一个机制,可能提供新的治疗点.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 系统性低度炎症与抑郁症的一个亚型有关.
- 选择性淋巴细胞低过综合征 (SGHS) 涉及基于囊素C (cysC) 的估计淋巴细胞过率 (eGFR) 与基于肌素 (crea) 的eGFR相对降低.
- SGHS与高水平的促炎标志物有关,但未在抑郁症中进行研究.
研究的目的:
- 调查SGHS作为炎症抑郁症的潜在机制.
- 为了比较难以治疗的抑郁症患者与对照者的SGHS患病率.
- 探索SGHS,炎症和抑郁症严重程度之间的关系.
主要方法:
- 在313名抑郁患者和73名对照患者中比较了SGHS患病率,使用各种eGFRcysC/eGFRcrea比率.
- 在276名抑郁患者中评估了血炎症标志物 (TNF-α,IFN-γ,IL-6,IL-8,IL-10).
- 研究了SGHS-抑郁症联系的IL-6调解.
主要成果:
- 抑郁症患者的SGHS患病率较高 (33.2%对比20.5%的比率<0.9;15.7%对比5.5%的比率<0.8).
- 较低的eGFRcysC/eGFRcrea比率与抑郁症患者炎症标志物增加相关.
- 互白素-6 (IL-6) 部分调解了SGHS和抑郁症之间的关联.
结论:
- 这项研究首先将SGHS与炎症性抑郁症联系起来.
- 在某些抑郁病例中,SGHS可能代表了相关的病理生理机制.
- 在独立的队列中进行进一步的研究可以验证SGHS作为抑郁症的治疗点.
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