不同寻常的eremophilanes的抗菌性质来自内生植物Diaporthe sp. BCC6951212 BCC6951212 BCC6951212 是一家在美国成立的公司
Chakapong Intaraudom1, Nantiya Bunbamrung1, Aibrohim Dramae1
1National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Phaholyothin Road, Klong Luang, Pathum Thani, 12120, Thailand.
Phytochemistry
|April 4, 2024
概括
来自Diaporthe真菌的新型埃雷莫菲兰衍生物显示出抗微生物和抗结核活性. 一些化合物表现出广泛的抗菌作用和对Mycobacterium tuberculosis的活性.
科学领域:
- 自然产品 化学 化学
- 菌类代谢学 菌类代谢学
- 药用化学 医学化学
背景情况:
- 内生菌是一种丰富的新生物活性二次代谢产物来源.
- 埃雷莫菲兰衍生物已知具有多种生物活性.
- 这种内菌是Diaporthe sp. BCC69512被调查其化学成分.
研究的目的:
- 从Diaporthe sp.中分离和表征新型的埃雷莫菲兰衍生物. BCC69512. 这是一个很大的问题.
- 评估分离化合物的生物活性,包括抗微生物,抗结核和细胞毒性.
主要方法:
- 使用色谱技术分离化合物.
- 使用NMR光谱学 (包括NOESY),莫舍尔方法和化学反应阐明结构.
- 生物活性查:抗疟疾,抗结核,抗植物病原性真菌,抗菌和细胞毒性检测.
主要成果:
- 发现了6种新的埃雷莫菲兰衍生物 (亚波特雷莫菲林A-F) 和一个新的侧链.
- 隔热热蛋白B和E表现出广泛的抗微生物活性,可以对抗M.结核病,B.麦,A.布拉西西科拉和C.急性菌 (MICs为25.0-50.0μg/mL).
- 测素显示出强烈的抗真菌活性 (MIC 3.13μg/mL),而热血林F和化合物8显示出抗结核活性 (MIC 50.0μg/mL).
结论:
- 这种内菌是Diaporthe sp. BCC69512生产具有显著抗微生物和抗结核潜力的独特的埃雷莫菲兰衍生物.
- 化合物2,5-7呈现出弱细胞毒性,但总体而言,与测试细胞系相比,分离的化合物在很大程度上是非细胞毒性.
- 这些发现凸显了真菌内细胞作为新型治疗剂来源的潜力.
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