在COVID-19之前和之后的症状:使用前性数据进行的人口和病例控制研究
Carole H Sudre1,2,3, Michela Antonelli1, Nathan J Cheetham4
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
The European respiratory journal
|April 4, 2024
概括
在COVID-19之前经历症状会增加长期疾病的风险. 许多长期COVID患者在感染前无症状,但先前存在的症状显著恶化了结果.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在2019年急性冠状病毒疾病 (COVID-19) 之后,大量人经历了长时间的症状.
- 感染前症状对后急性COVID疾病持续时间的影响仍然是研究领域.
研究的目的:
- 评估感染前症状对后急性COVID疾病的持续时间和严重性的影响.
- 为了确定与长期COVID-19症状相关的风险因素.
主要方法:
- 对23452名患有严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染的成年人的生存分析,使用ZOE COVID症状研究应用程序的数据.
- 一项病例对照研究与1:1匹配 (n=1350对),比较长期疾病 (≥8周) 与短期疾病 (<4周) 的个体,分析基线症状 (感染前4-8周).
主要成果:
- 患有感染前症状的个体有较长的COVID相关症状持续时间 (中位数为15天而不是10天).
- 基线疲劳几乎使症状持续时间翻了一番. 感染前的症状使长期疾病的几率翻了一番 (OR 2.14).
- 虽然许多长期COVID患者事先没有症状 (67.4%),但很大一部分 (32.6%) 患有基线症状,而短期疾病组 (p<0.0001) 的症状为18.9%.
结论:
- 在COVID-19感染之前已经存在的症状与更长的疾病持续时间和患上长期COVID的几率增加有关.
- 在长期COVID患者中,很大一部分在SARS-CoV-2感染之前没有症状,这表明了其他促成因素.
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