减少皮层厚度与COVID-19后的认知功能障碍相关:从长期随访的见解
Rosalia Dacosta-Aguayo1,2, Josep Puig3,4, Noemi Lamonja-Vicente1,5
1From the Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol) (R.D.-A., N.L.-V., M.C.-C., B.B.L.-G., V.M.L.-L., V.Z.-P., P.M.-A., C.C., J.B., E.M.-G., R.G.-S., A.P., A.C., C.V., P.T.-M.), Unitat de Suport a la Recerca Metropolitana Nord, Mataró, Spain.
AJNR. American journal of neuroradiology
|April 4, 2024
概括
在COVID-19后的长期认知缺陷与大脑结构变化有关. 这项研究揭示了持续的神经成像改变与持续的认知障碍相关的新冠病毒疾病2019 (COVID-19) 后持续的认知障碍.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是指放射学
- 认知科学 认知科学
背景情况:
- 关于2019年新冠病毒 (COVID-19) 后病情患者的长期神经成像发现的数据有限.
- 在这个人群中,很少有研究将认知评估与结构性MRI相关联.
研究的目的:
- 为了研究COVID-19后患者的长期认知结果.
- 在COVID-19后的条件下,将认知发现与结构性MRI数据相关联.
主要方法:
- 53名COVID-19后病情的参与者接受了3T脑部MRI (T1和FLAIR序列),SARS-CoV-2感染后的中位数为1.8年.
- 一个全面的神经心理学电池评估认知领域,并与全脑基于voxel的形态学和FreeSurferROI进行了相关性.
主要成果:
- 超过一半的参与者表现出注意力 (55%) 和执行力 (59%) 的缺陷;40%的记忆力受损.
- 在左侧准海马和右尾巴中额头区域的皮质厚度降低与记忆领域的表现正相关.
结论:
- 在COVID-19后的认知障碍与长期的大脑结构变化有关.
- 这些宏观结构变化可能为COVID-19后经历的认知症状的性质提供了洞察力.
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