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Updated: May 5, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
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对超级解析的现场测序数据的计算分析揭示了因免疫-瘤接触事件而改变的基因

Michal Danino-Levi1,2,3, Tal Goldberg1,2,3, Maya Keter1

  • 1The Alexander Kofkin Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.

RNA (New York, N.Y.)
|April 4, 2024
PubMed
概括

这项研究揭示了癌细胞如何与免疫细胞相互作用,通过分析基因表达的变化. 它在CD8 T细胞中识别了特定的基因,这些基因因因接近瘤细胞而被激活,从而提供了对免疫逃避的见解.

关键词:
通过RNA成像进行RNA成像.癌症生物学 癌症生物学细胞细胞相互作用基因组学就是基因组学.空间基因组学的空间基因组学

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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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