慢性肺炎:慢性呼吸系统衰竭和没有慢性呼吸系统衰竭的患者的铁缺乏症和临床特征
Ingrid Marie Hardang1,2, Vidar Søyseth2,3, Natalia Kononova2,4
1Department of Multidisciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norway.
在慢性阻塞性肺病 (COPD) 中,铁缺乏是常见的,特别是在严重的疾病中. 虽然与支气管阻塞和吸烟有关,但在这项COPD患者研究中,它没有增加死亡率.
科学领域:
- 肺部医学 肺部医学
- 血液学 血液学 血液学
- 营养科学 营养科学
背景情况:
- 在慢性阻塞性肺病 (COPD) 中缺铁的患病率在研究中不一致.
- 了解铁缺乏症对于管理COPD患者至关重要,影响疾病特征和结果.
研究的目的:
- 用三种既定标准来确定COPD患者的铁缺乏患病率.
- 调查铁缺乏症和COPD临床特征之间的关联.
- 评估铁缺乏和COPD死亡率之间的关系.
主要方法:
- 一项队列研究包括84名COPD患者和59名对照人群,评估了6.5年内费里丁,转激素和 (TSat) 和死亡率.
- 后勤回归分析了缺铁与临床特征之间的关联.
- 混合效应的考克斯回归模型检查了与死亡率的关联.
主要成果:
- 根据标准,缺铁的患病率在10%-43%之间,在COPD中更高 (在慢性呼吸衰竭中高达71%).
- 低费里丁与较低的FEV1,吸烟和心血管疾病相关;低TSat与BMI和血红蛋白相关.
- 铁缺乏和死亡率之间没有发现显著的关联 (HR 1.2-1.8).
结论:
- 铁缺乏症的患病率随着COPD的严重程度而升级.
- 特定的缺铁标志物与支气管阻塞,吸烟,心血管疾病,BMI和血红蛋白水平有关.
- 这项研究没有发现铁缺乏会增加COPD患者的死亡率的证据.
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