在患有前列腺癌的男性中,与抑郁症相关的死亡风险
Casey Crump1, Pär Stattin2, James D Brooks3
1Department of Family and Community Medicine, The University of Texas Health Science Center, Houston, TX, USA; Department of Epidemiology, The University of Texas Health Science Center, Houston, TX, USA.
European urology oncology
|April 4, 2024
概括
患有前列腺癌 (PC) 的男性患有严重抑郁症,死亡风险明显增加. 早期发现和治疗抑郁症对于改善PC患者的长期生存至关重要.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 前列腺癌 (PC) 患者患抑郁症的发病率较高.
- 抑郁症对PC幸存者的长期生存的影响仍未得到充分研究.
- 了解这种关联对于改善患者护理和治疗结果至关重要.
研究的目的:
- 在全国范围内一组被诊断患有前列腺癌的男性中,调查主要抑郁症和死亡率之间的联系.
- 量化抑郁症与所有原因和PC特定死亡率之间的关联.
主要方法:
- 一项国家队列研究包括了180,189名在瑞典被诊断患有PC的男性 (1998-2017年).
- 大型抑郁症的诊断是从全国性的健康记录中确定出来的.
- 考克斯回归和竞争风险模型被用于分析死亡率,并对相关共变量进行调整.
主要成果:
- 在130万人年随访期间,9%的PC患者被诊断出严重抑郁症.
- 在患有PC和重度抑郁症的男性中观察到调整后50%的全因死亡风险增加 (HR 1.50-1.64).
- 增加的PC特定死亡率也与严重抑郁症相关 (HR 1.35-1.42).
结论:
- 重度抑郁症与PC男性全因和前列腺癌特异性死亡率的增加显著相关.
- 这些发现强调了对PC患者抑郁症及时识别和管理的必要性.
- 对抑郁症的及时干预可能会改善前列腺癌男性的长期生存和结果.
相关概念视频
Disorders of the Male Reproductive System
404
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
404
Psychoneuroimmunology: Diabetes and Cancer
28
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
28
Menopause
157
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
157
Depressive Disorders: Etiology
83
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
83
Stress and Mental Health
155
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
155
Cancer Survival Analysis
345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345


