关于前列腺癌老年患者的研究结果:系统性审查
Kim F T Jochems1, Dominik Menges2, Dafne Sanchez2
1Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland; Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Journal of geriatric oncology
|April 4, 2024
概括
这次审查发现,老年人前列腺癌的临床研究主要侧重于生存和疾病进展. 未来的研究应该包括与这一群体相关的生活质量和功能结果.
科学领域:
- 老年瘤学 老年瘤学
- 临床研究方法论 临床研究方法论
- 前列腺癌治疗方法 前列腺癌治疗方法
背景情况:
- 老年人经常被排除在临床研究之外.
- 现有的结果测量可能不适合对老年患者的治疗进行评估.
- 前列腺癌研究往往忽视了65岁及以上患者的具体需求.
研究的目的:
- 对65岁及以上的前列腺癌患者的临床研究中使用的结果测量方法进行系统审查.
- 在涉及老年前列腺癌患者的研究中确定不同结果类别的患病率.
- 突出与老年人群相关的结果评估中的差距.
主要方法:
- 在PubMed和Embase数据库 (2016-2023) 的系统文献搜索.
- 包括65岁及以上患者前列腺癌治疗的研究.
- 对研究设计,参与者人口统计,疾病阶段,治疗和调查结果的描述性分析.
主要成果:
- 包括68项研究,其中大多数专注于65岁以上的患者.
- 与生存相关的结果 (57.3%) 和毒性/不良事件 (55.9%) 是最常见的.
- 与健康相关的生活质量 (29.4%) 和功能结果 (29.4%) 的研究较少.
结论:
- 目前对老年人进行的前列腺癌研究主要是研究生存率和疾病进展.
- 显著缺乏关注与健康相关的生活质量和功能结果,这是老年患者的优先事项.
- 未来的研究必须采用针对老年人群的结果措施,以加强对老年前列腺癌患者的护理.
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