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Updated: Jun 29, 2025

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调节线粒体中的Lars2:通过抑制陶酸化来作为潜在的阿尔茨海默病治疗方法

Wenqi Qian1, Lin Yuan2, Weishan Zhuge3

  • 1Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
|April 4, 2024
PubMed
概括

研究人员将Lars2确定为潜在的阿尔茨海默病 (AD) 目标. 这种酶的下调会损害线粒体功能,导致蛋白酸化和神经元死亡,这表明Lars2是治疗候选者.

关键词:
阿尔茨海默病 (AD) 是一种疾病.基-tRNA合成酶2是什么意思线粒体中的线粒体.在PI3K/AKT/GSK3β轴上

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