酒精和大麻量对年轻成年人同日负面后果预测的互动效应
Jeffrey D Wardell1,2,3, Sophie G Coelho1, Kyra N Farrelly1
1Department of Psychology, York University, Toronto, Ontario, Canada.
Alcohol, clinical & experimental research
|April 4, 2024
概括
同时使用酒精和大麻会导致更多的负面后果. 然而,较高的大麻花量可能会减轻与较低的酒精消费相关的负面影响,这表明剂量-数量相互作用是关键.
科学领域:
- 成研究研究成研究
- 药物使用流行病学.
- 行为毒理学行为毒理学
背景情况:
- 同时使用酒精和大麻的情况很普遍.
- 很少有研究检查过酒精和大麻之间剂量反应相互作用的负面影响.
- 了解这些相互作用对于公共卫生和减少危害至关重要.
研究的目的:
- 调查酒精和大麻量之间与剂量相关的相互作用,以预测负面后果.
- 为了比较同时使用日和单一物质使用日之间的负面影响.
主要方法:
- 报告每周使用酒精和大麻的151名年轻人完成了每天21次智能手机调查.
- 评估前一天的酒精和各种大麻形式 (花,缩物,食用品) 的量.
- 多级模型分析了负面后果和剂量相互作用的个体内差异.
主要成果:
- 同时使用的日子与仅饮酒或仅吸食大麻的日子相比,与更多的负面后果有关.
- 在使用大麻花的日子里,更多的大麻花削弱了酒精量和负面影响之间的关联.
- 当与较高的大麻花数量相结合时,减少酒精消费的负面影响下降较小.
结论:
- 虽然同时使用会增加负面影响,但酒精和大麻量之间的相互作用会调节这些影响.
- 较高的大麻花消费可能会减轻与较低的酒精摄入量相关的负面影响.
- 高风险同时使用的干预措施应考虑这两种物质的数量.
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