基于人口的队列研究,以调查韩国亚托皮性皮肤炎患者使用的流行率,严重程度和治疗方式的变化
Hyun Ji Lee1, Hyun Ju Oh2, Gyu Na Lee3
1Department of Dermatology, Yeouido St. Mary's Hospital, Seoul, Korea.
Scientific reports
|April 4, 2024
概括
在韩国,2002-2019年间,亚托皮炎 (AD) 的患病率增加,特别是在青少年和成年人中. 尽管严重程度上升,但治疗仍然依赖于皮质类固醇,突出显示需要新的指导方针.
科学领域:
- 皮肤病学 皮肤病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 亚托匹性皮肤炎 (AD) 是一种慢性炎症性皮肤疾病,具有重大公共卫生影响.
- 了解AD流行,严重程度和治疗的长期趋势对于有效的医疗管理至关重要.
研究的目的:
- 分析2002年至2019年期间在韩国发生的亚托皮炎流行,严重程度和治疗模式的趋势.
- 为了识别AD的人口变化,并评估当前治疗策略的适当性.
主要方法:
- 对355,277名被诊断患有AD的韩国患者的国家医疗保险系统数据的回顾性分析.
- 数据涵盖了18年 (2002-2019),检查了不同年龄组的流行率和治疗处方的变化.
主要成果:
- 韩国的AD总体患病率从3.88%增加到5.03%.
- 患病率在婴儿 (0-1岁) 中下降,但在青少年 (12-19岁) 和成年人 (≥20岁) 中显著增加.
- 中度至重度AD病例的比例增加,但皮质类固醇处方仍然是主要治疗方法,显示最小的变化.
结论:
- 在韩国青少年和成年人中,亚托邦性皮肤炎正在增加,越来越多的人患有中度至严重的疾病.
- 目前的治疗模式严重依赖于皮质类固醇,这表明在解决不断升级的AD严重程度方面存在潜在差距.
- 建议制定更新的治疗指南,包括生物药物,以提高AD管理的有效性和安全性.
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