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Updated: Apr 30, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
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分子动力学模拟以探索粉样β蛋白前体 (APP) 和适应蛋白 Mint2 之间的结合模式

Min Wang1,2, Kaifeng Liu3

  • 1International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun, 130022, China. wangm@cust.edu.cn.

Scientific reports
|April 4, 2024
PubMed
概括

这项研究揭示了突变的Mint2蛋白如何在阿尔茨海默病 (AD) 研究中更有效地与粉样蛋白前体蛋白 (APP) 结合. 了解这种相互作用可能会导致AD预防和治疗的新疗法.

关键词:
适配蛋白 Mint2 (((Mint2) 是一个适配蛋白.氨基酸β (Aβ) 蛋白质前体 (APP) 的前体形状的变化 形状的变化在MM-PBSASA中使用.分子动力学模拟的模拟.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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