HbA1c或果糖胺在评估患有β-血病的儿童的葡萄糖不耐受性
Asmaa A Mahmoud1, Mahmoud A El-Hawy2, Esraa T Allam3
1Department of Pediatrics, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt. asmaasoliman50@gmail.com.
大型β-thalassemia患者通常具有葡萄糖不耐受性. 果糖胺在检测糖尿病方面比HbA1c更敏感,在这些儿童中,胰岛素耐药性是常见的.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 儿科 儿科 儿科
背景情况:
- 大型β-thalassemia (β-TM) 与葡萄糖不耐症的风险增加有关.
- 目前用于评估β-TM患者的葡萄糖不耐受性的血液标志物正在争论中.
- 胰岛素抵抗是β-TM中葡萄糖代谢异常的一个潜在因素.
研究的目的:
- 评估糖化血红蛋白A1c (HbA1c) 和果糖胺,以检测β-TM儿童的葡萄糖不耐受性.
- 评估胰岛素抵抗在β-TM儿童葡萄糖不耐症中的作用.
主要方法:
- 研究了100名β-TM儿童和100名对照儿童.
- 评估的禁食血葡萄糖 (FPG),2小时的食后葡萄糖 (2小时的PG),HbA1c,果糖胺,禁食胰岛素 (FINS),HOMA-IR和HOMA-IS.
- 患者和对照组之间的血糖标记和胰岛素抵抗指数的比较.
主要成果:
- 51%的β-TM患者表现出葡萄糖不耐受,其中19人被诊断为糖尿病.
- 在β-TM患者和对照患者中,HbA1c,果糖胺,FINS和HOMA-IR显著升高 (P < 0.001).
- 与HbA1c相比,果糖胺对糖尿病前期的特异性和对糖尿病检测的敏感性更高.
结论:
- 尽管存在争议,但HbA1c仍然对 β-TM 儿童的葡萄糖不耐受性检测有价值.
- 果糖胺在这种人群中显示出更高的灵敏度和特异性来诊断葡萄糖异常.
- 胰岛素抵抗在β-TM的儿童中很普遍,需要定期监测血糖水平.
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