人类白细胞抗原变异与BNT162b2 mRNA疫苗反应有关
Martina Esposito1, Francesca Minnai1,2, Massimiliano Copetti3
1National Research Council, Institute for Biomedical Technologies, Segrate, MI, Italy.
Communications medicine
|April 4, 2024
概括
人类白细胞抗原 (HLA) 基因会影响抗体对瑞生物科技COVID-19疫苗的反应. 遗传变异,特别是HLA-A,HLA-DQA1和HLA-DQB1,显著影响疫苗的有效性和抗体水平.
科学领域:
- 免疫遗传学 免疫遗传学
- 疫苗学 疫苗学 疫苗学
- 基因组学就是基因组学.
背景情况:
- 在COVID-19疫苗反应中,个体间的变异性表明宿主遗传因素的作用.
- 之前的研究表明,人类白细胞抗原 (HLA) 基因等位基因对牛津-阿斯特拉泽内卡疫苗的反应有影响.
研究的目的:
- 为了研究抗体对瑞-生物科技疫苗反应的遗传决定因素.
- 为了识别与疫苗免疫性相关的特定人类白细胞抗原 (HLA) 基因.
主要方法:
- 全基因组关联研究 (GWAS) 在意大利一组1351名受试者中.
- 对700多万个遗传变异和204个HLA等位基因对正常化抗体水平的分析.
- 线性回归模型根据包括性别,年龄和接种疫苗后的时间在内的共同变量进行调整.
主要成果:
- 在HLA-A,HLA-DQA1和HLA-DQB1基因中的抗体水平和变异之间发现了显著的关联.
- HLA-A*03:01等位基因与血清抗SARS-CoV-2抗体水平的关联最强.
- 多个HLA类I和II等位基因与抗体反应有显著的联系.
结论:
- HLA基因在调节瑞生物科技疫苗免疫反应方面发挥着重要作用.
- 强调需要对不同人群进行遗传研究,以了解疫苗反应.
- 建议进行功能性研究,探索HLA-A*03:01和CD8+T细胞反应之间的联系.
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