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Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

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用于组织工程应用的可生物降解的基于接开发的白蛋白复合材料.

Mohamed A Naser^1,2, Ahmed M Sayed^3,4, Wael Abdelmoez⁵

¹Faculty of Engineering, Biomedical Engineering Department, Minia University, Minia, Egypt. mohamed.nasser@mu.edu.eg.

Scientific reports

|April 4, 2024

概括

研究人员从人血清中白蛋白,一种可生物降解的蛋白质中开发出了一种新. 这种新材料显示出各种医疗用途的有希望的机械性能,解决了当前生物材料的局限性.

关键词:

可生物降解的材料.挤出过程中的挤出工艺.血清中白蛋白的使用.手术 sutures 手术 sutures 手术 sutures 手术 sutures 手术 sutures 手术 sutures 组织工程的应用.

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科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
再生医学是一种再生医学.

背景情况:

生物降解材料对于组织再生疗法至关重要.
当前的生物材料 (陶,聚合物,金属,复合材料) 有诸如组织融合不良和机械不匹配等局限性.
基于蛋白质的复合材料提供了增强的生物降解性和生物相容性.

研究的目的:

开发和描述一个创新的接从人血清白蛋白 (HSA) 使用挤出.
为了评估HSA的物理化学特性.
评估可生物降解有机修饰剂对机械性能的影响.

主要方法:

通过挤出,从人类血清白蛋白制造.
使用拉伸试验,扫描电子显微镜 (SEM) 和热重力测量分析 (TGA) 进行表征.
机械性质的评估与没有生物可降解的有机修饰剂.

主要成果:

预先的拉力测试显示,拉力强度从1.3到9.616MPa.
断裂时的延长率在11.5%至146.64%之间,表明机械的多功能性.
目前正在进行SEM和TGA分析以确定形态和热性质.

结论:

开发出来的人体血清白蛋白接表现出可调节的机械性能.
可生物降解的有机修饰剂可以提高的机械完整性.
这种基于蛋白质的新 suture 具有各种生物医学应用的潜力.