用于组织工程应用的可生物降解的基于接开发的白蛋白复合材料
Mohamed A Naser1,2, Ahmed M Sayed3,4, Wael Abdelmoez5
1Faculty of Engineering, Biomedical Engineering Department, Minia University, Minia, Egypt. mohamed.nasser@mu.edu.eg.
Scientific reports
|April 4, 2024
概括
研究人员从人血清中白蛋白,一种可生物降解的蛋白质中开发出了一种新. 这种新材料显示出各种医疗用途的有希望的机械性能,解决了当前生物材料的局限性.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 再生医学是一种再生医学.
背景情况:
- 生物降解材料对于组织再生疗法至关重要.
- 当前的生物材料 (陶,聚合物,金属,复合材料) 有诸如组织融合不良和机械不匹配等局限性.
- 基于蛋白质的复合材料提供了增强的生物降解性和生物相容性.
研究的目的:
- 开发和描述一个创新的接从人血清白蛋白 (HSA) 使用挤出.
- 为了评估HSA的物理化学特性.
- 评估可生物降解有机修饰剂对机械性能的影响.
主要方法:
- 通过挤出,从人类血清白蛋白制造.
- 使用拉伸试验,扫描电子显微镜 (SEM) 和热重力测量分析 (TGA) 进行表征.
- 机械性质的评估与没有生物可降解的有机修饰剂.
主要成果:
- 预先的拉力测试显示,拉力强度从1.3到9.616MPa.
- 断裂时的延长率在11.5%至146.64%之间,表明机械的多功能性.
- 目前正在进行SEM和TGA分析以确定形态和热性质.
结论:
- 开发出来的人体血清白蛋白接表现出可调节的机械性能.
- 可生物降解的有机修饰剂可以提高的机械完整性.
- 这种基于蛋白质的新 suture 具有各种生物医学应用的潜力.
关键词:
可生物降解的材料.挤出过程中的挤出工艺.血清中白蛋白的使用.手术 sutures 手术 sutures 手术 sutures 手术 sutures 手术 sutures 手术 sutures组织工程的应用.更多相关视频
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
11.8K
08:40TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
Published on: June 8, 2016
14.2K
相关概念视频
Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
Production of Organic Acids
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Biological Treatment of Effluent and Waste Water
Biological wastewater treatment relies on the metabolic activity of microorganisms to remove pollutants from sewage. In modern treatment systems, this process is organized into sequential stages that progressively reduce solid material, dissolved organic matter, and microbial contamination. Each stage plays a distinct role in improving water quality and preparing the effluent for safe discharge or reuse.Primary and Secondary TreatmentPrimary treatment is a physical process that removes large...
Microbial Bioremediation of Plastics
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
Downstream Processing
Downstream processing begins once fermentation is complete and involves a series of steps to recover and purify products such as acids, vitamins, antibiotics, or proteins.Cell HarvestingFor example, for intracellular protein-based products, the first step is harvesting the cells. This is typically achieved using centrifugation or filtration to separate the cells from the liquid phase.Cell Disruption for Intracellular ProductsIf the target product is intracellular, the harvested cells must be...
