胃多的长期内镜变化与vonoprazan的管理相关
Yorinari Ochiai1, Shinji Ito2, Daisuke Kikuchi3
1Department of Gastroenterology, Toranomon Hospital, Tokyo, 105-8470, Japan. y.ochiai.1987@gmail.com.
Clinical journal of gastroenterology
|April 4, 2024
概括
沃诺普拉桑 (VPZ) 是一种与竞争的酸阻塞剂,可能会导致胃聚合体. 这份病例报告显示,在停止服用药物后,VPZ诱导的胃息肉可能会缩小,这表明可逆的内镜变化.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 内镜检查是指内镜检查.
背景情况:
- 质子抑制剂 (PPI) 与胃粘膜变化有关,如多.
- 沃诺普拉赞 (VPZ) 是一种与相竞争的酸阻断剂,与胃息肉之间的关系尚未得到充分证实.
- 长期的酸性抑制会导致高胃血,可能导致胃粘膜的变化.
研究的目的:
- 调查长期Vonoprazan (VPZ) 管理与胃息肉发育之间的潜在联系.
- 评估VPZ相关的内镜变化的可逆性,特别是胃聚合体,在药物停用后.
主要方法:
- 一个65岁的男性患者的病例报告,患有反流食道炎,不耐PPI治疗.
- 诺普拉桑 (VPZ) 用于抑制酸性.
- 连续食道胃二门视镜 (EGD) 用于监测胃粘膜变化和多胞体大小在五年内.
- 在停止VPZ治疗后评估聚变化.
主要成果:
- 患者在五年使用VPZ期间在心脏中逐渐扩大的胃聚.
- 聚的尺寸约为10毫米,呈现出红色的外观与白色的物质.
- 在停止VPZ治疗一年后,胃聚显著缩小至5毫米.
- 这表明VPZ和胃息肉生长之间存在潜在的因果关系.
结论:
- 长期使用Vonoprazan (VPZ) 可能会导致胃息肉的发展和扩大.
- 停止VPZ治疗可能会导致这些胃聚体的大小可逆性减少.
- 需要进一步的研究来了解VPZ诱导的胃变化的机制和临床意义.
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