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增加SEC14L2表达与临床病理特征和口腔状细胞癌的更差预后有关

Jonah Justin David¹, Balachander Kannan², Chandra Pandi²

¹Department of Periodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.

|April 4, 2024

概括

在口腔状细胞癌 (OSCC) 和头状细胞癌 (HNSCC) 中,SEC14L2的表达很高,与患者存活率较差和疾病晚期相关.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症基因组学癌症基因组学

背景情况:

SEC14L2异常表达与各种人类癌症有关.
在口腔状细胞癌 (OSCC) 中SEC14L2的特定作用需要阐明.

研究的目的:

为了研究OSCC中SEC14L2的表达模式.
确定SEC14L2在OSCC和头角状细胞癌 (HNSCC) 的预后意义.

主要方法:

定量逆转录PCR (RT-qPCR) 用于mRNA表达分析.
对癌症基因组图谱-头状细胞癌 (TCGA-HNSCC) 数据集进行临床相关性的分析.
卡普兰-梅尔生存分析和瘤免疫估计资源 (TIMER) 数据库用于免疫细胞透评估.
通过蛋白质-蛋白质相互作用网络进行途径分析的in silico工具.

主要成果:

与相邻的正常组织相比,OSCC和HNSCC组织中的SEC14L2mRNA和蛋白质水平显著升高.
高SEC14L2表达与晚期瘤阶段,等级,转移,HPV阴性和TP53突变相关.
升高的SEC14L2与患者存活率降低和免疫细胞透率降低有关.

结论:

在OSCC/HNSCC中,SEC14L2受到上调,并作为预后不良的潜在生物标志物.
需要进一步的研究来探索SEC14L2在头癌的治疗潜力,以改善患者的治疗结果.

关键词:

遗传学是一个遗传学.卫生健康卫生健康卫生健康免疫系统的透.死亡率死亡率死亡率这是OSCCCC的OSCC.预测指标是一个预测指标.

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