由于社区相关的甲素耐药黄金葡萄球菌引起的复发性支气管肺炎:一个病例报告
Sho Shimada1, Tetsuo Yamaguchi2, Satsuki Mikoshiba3
1Department of Respiratory Medicine, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8519, Japan. shi2pulm@tmd.ac.jp.
BMC infectious diseases
|April 4, 2024
概括
社区相关的甲素耐药黄金葡萄球菌 (CA-MRSA) 可以导致严重的呼吸道感染. 一个罕见的复发性MRSA支气管肺炎病例通过6个月的trimethoprim/sulfamethoxazole (TMP/SMX) 治疗成功治疗.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 肺部病理学 肺部病理学
背景情况:
- 与社区相关的甲素耐药黄金葡萄球菌 (CA-MRSA) 感染正在增加.
- 呼吸道感染通常是严重的,但需要长期治疗的复发不常见.
研究的目的:
- 报告一种罕见的复发性CA-MRSA支气管肺炎病例.
- 为了突出长期抗生素治疗复发性MRSA呼吸道感染的有效性.
主要方法:
- 一个56岁的男性患者的病例报告,患有复发性支气管肺炎.
- 导致CA-MRSA菌株的隔离和全基因组测序.
- 治疗时间延长的口服trimethoprim/sulfamethoxazole (TMP/SMX).
主要成果:
- 患者经历了MRSA支气管肺炎的反复复发,尽管最初的抗生素治疗.
- 全基因组测序确定了该菌株为序列类型 (ST) 1 / 葡萄球菌带染色体mec (SCCmec) 类型 IVa.
- 六个月的TMP/SMX治疗成功控制了感染,并且耐受良好.
结论:
- 这种病例呈现出MRSA支气管肺炎的异常发展过程,频繁复发.
- 长期的TMP/SMX治疗可以有效地管理复发的MRSA呼吸道感染.
- 新出现的ST1/SCCmec类型IVa克隆需要进一步的临床和流行病学研究.
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