Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Prognostic significance of genome-wide DNA methylation profiles within the randomized, phase 3, EORTC CATNON trial on non-1p/19q deleted anaplastic glioma.

Neuro-oncology·2021
Same author

DNA Methylation Profiling Discriminates between Malignant Pleural Mesothelioma and Neoplastic or Reactive Histologic Mimics.

The Journal of molecular diagnostics : JMD·2021
Same author

Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas.

Cancer discovery·2021
Same author

Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1.

Acta neuropathologica·2021
Same author

Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2021
Same author

Neurofibromatosis type 2 predisposes to ependymomas of various localization, histology, and molecular subtype.

Acta neuropathologica·2021

相关实验视频

Updated: Jun 26, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

11.8K

EpiDiP/NanoDiP:一个多功能无监督的机器学习边缘计算平台,用于表观基因瘤诊断.

Jürgen Hench1, Claus Hultschig2, Jon Brugger2

  • 1Institut für Medizinische Genetik und Pathologie, Universitätsspital Basel, Schönbeinstr. 40, 4031, Basel, Switzerland. juergen.hench@usb.ch.

Acta neuropathologica communications
|April 4, 2024
PubMed
概括

一个新的开源套件,EpiDiP/NanoDiP,提供精确的DNA甲基化和复制号分析,用于在各种测序方法中进行诊断瘤类型. 它在边缘设备上离线运行,确保数据隐私,并允许快速的内部分类.

关键词:
人工智能的人工智能是人工智能.复制号码 概况编制 复制号码加密货币矿工是什么意思数字病理学数字病理学缩小尺寸的缩小方式边缘计算是一种边缘计算.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.在外科手术内进行.甲基化 甲基化 甲基化甲基化序列的排列方式甲基组组是指甲基组组中的一种.微阵列的微阵列纳米孔测序的测序在瘤学瘤学.同一天的分类.这就是为什么SoC SoC.瘤是一个瘤.这就是UMAP UMAP.无监督的机器学习在 gpGPU 中.

更多相关视频

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.4K
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.6K

相关实验视频

Last Updated: Jun 26, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

11.8K
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.4K
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.6K

科学领域:

  • 表观遗传学和分子诊断学
  • 计算生物学和生物信息学
  • 瘤学和病理学

背景情况:

  • DNA甲基化分析对于精确的瘤类型定型至关重要,微阵列和纳米孔序列是常见的方法.
  • 现有的工具缺乏对各种甲基化分析数据 (微阵列,纳米孔,并行测序) 和离线操作的全面支持.
  • 需要集成软件,可以处理各种数据类型,控制序列,并在资源有限的诊断实验室运行.

研究的目的:

  • 介绍EpiDiP/NanoDiP,这是一个开源套件用于DNA甲基化和复制号分析.
  • 为分类和解释微阵列,纳米孔和并行测序数据提供一个多功能工具.
  • 为了快速诊断瘤分类,在边缘计算设备上实现离线,保护隐私的分析.

主要方法:

  • 开发和对EpiDiP/NanoDiP开源DNA甲基化和副本编号分析套件进行基准测试.
  • 利用2019-2021年公司内部常规诊断数据,与已有的监督机器学习方法进行基准测试.
  • 设计用于在成本和节能边缘计算设备 (System-on-Chip,gpGPU增强) 在离线模式下进行本地操作.

主要成果:

  • EpiDiP/NanoDiP成功地分类和解释来自不同测序平台的DNA甲基化和拷贝数数据.
  • 该软件在边缘设备的离线模式下有效运行,确保数据隐私并实现快速分析.
  • 基准测试证实了其与既有方法相比的性能,并有可能用于手术内分子瘤分类.

结论:

  • EpiDiP/NanoDiP解决了现有工具的局限性,为DNA甲基化分析提供了一个统一的,多功能平台.
  • 该套件促进了快速,保护隐私的瘤分类,支持诊断常规和表观遗传学研究.
  • 它是病理学家和研究人员的宝贵资源,提高了诊断精度和效率.