益生菌寡糖类对功能性便秘儿童的肠道习惯和肠道微生物群的影响 (内部研究):随机,安慰剂控制,多中心试验的研究方案
Carrie A M Wegh1,2, Margriet H C Schoterman3, Elaine E Vaughan4
1Department of Paediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. carriewegh@gmail.com.
Trials
|April 4, 2024
概括
这项研究调查了益生菌寡糖是否可以改善幼儿的便秘症状. 这项研究旨在为这种常见的儿科胃肠道问题提供证据.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 功能性便秘 (FC) 影响全球9.5%的儿童,导致不频繁,疼痛的便和腹痛.
- 已知 prebiot oligosaccharides 可以缓解成年人的便秘,但它们在患有 FC 的儿童中的有效性尚未得到充分研究.
- 目前的证据不足以证实 prebiot oligosaccharides 对儿科功能性便秘的益处.
研究的目的:
- 评估两种益生菌寡糖在改善1-5岁儿童便秘症状方面的有效性.
- 评估益生菌对FC儿童便一致性,频率,疼痛和生活质量的影响.
- 探索益生菌补充剂对小儿FC肠道微生物组合和代谢物的影响.
主要方法:
- 一项随机,双盲,安慰剂控制的多中心研究,涉及12-72个月龄的儿童,被诊断患有FC (罗马第四标准).
- 参与者接受了两种益生菌寡糖之一或安慰剂8周,然后是4周的洗期.
- 主要结局:便一致性的变化;次要结局:便频率,痛苦的排便,药物使用,生活质量和肠道微生物组分析.
主要成果:
- 本节不适用,因为摘要描述的是研究方案,而不是研究结果.
- 本节不适用,因为摘要描述的是研究方案,而不是研究结果.
- 本节不适用,因为摘要描述的是研究方案,而不是研究结果.
结论:
- 这项研究将提供关于益生菌寡糖在治疗幼儿功能性便秘方面的有效性至关重要的数据.
- 预计这些发现将为临床实践提供信息,并可能为儿科FC提供新的治疗选择.
- 研究对肠道微生物群的影响可能会揭示益生菌在儿童便秘中的潜在作用机制.
关键词:
我们的肠道习惯是排便.功能性便秘是一种功能性便秘.胃肠病学 胃肠病学我们的肠道微生物群.营养 营养 营养 营养 营养橄糖 橄糖 橄糖儿科 儿科 儿科益生菌 益生菌 益生菌便的一致性 便的一致性便的频率 便的频率更多相关视频
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