相关实验视频

Updated: Jun 29, 2025

Assays for Validating Histone Acetyltransferase Inhibitors

Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

向组织素脱甲基酶JMJD3和UTX:作为宫癌的潜在治疗剂

Dezhi Chen^1,2, Bo Cai^2,3, Yingying Zhu¹

¹Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, 315100, Zhejiang Province, China.

Clinical epigenetics

|April 4, 2024

概括

通过向JMJD3和UTX. histone脱甲基酶来抑制宫癌的生长. 抑制这些酶可以模仿.

科学领域:

在瘤学瘤学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
营养科学营养科学

背景情况:

已知在降低癌症风险方面的潜力.
它在子宫癌表观遗传学中的作用尚未得到充分探索.

研究的目的:

研究对子宫癌的影响.
在宫癌中确定的分子标.

主要方法:

在宫癌细胞和器官的体外和体内研究.
抑制基因组脱甲基酶JMJD3和UTX的发生.
对H3K27me3修饰的ChIP-qPCR分析.

主要成果:

抑制了宫癌细胞的增殖,迁移,入侵,并促进了细胞亡.
在体内抑制了瘤的生长.
抑制JMJD3和UTX模仿了的作用,诱导G2/M停止,亡,并逆转EMT.
在宫癌组织中,JMJD3和UTX过度表达.

结论:

具有显著的抗宫癌潜力.
在宫癌中,JMJD3和UTX是的主要分子标.
准JMJD3和UTX为宫癌提供了一个潜在的治疗策略.

关键词:

宫癌是发生在宫癌的原因之一.H3K27甲基化 H3K27甲基化 JMJD3D3 在线阅读是一种.UTX UTX UTX UTX UTX UTX是什么意思

更多相关视频

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Published on: January 16, 2015

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Histone Variants at the Centromere

Histone Variants at the Centromere

Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...