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神经心理功能及其相关物质在重症COVID-19的1年随访后
Ana Costas-Carrera1, Marta Mónica Sánchez-Rodríguez1, Antonio Ojeda2
1Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
概括
严重的COVID-19患者在重症监护室 (ICU) 退院一年后表现出认知能力的改善,特别是在记忆力和执行功能方面. 然而,近一半的人仍然经历了神经认知缺陷,受到焦虑和抑郁的影响.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
背景情况:
- 短期认知障碍是SARS-CoV-2感染的一个已知的后果.
- 严重的COVID-19幸存者的长期认知后果,特别是来自重症监护室 (ICU) 的患者,需要详细检查.
研究的目的:
- 在ICU退院一年后,调查严重COVID-19患者认知症状的长期演变.
- 为了确定与持续的神经认知缺陷相关的临床相关性.
主要方法:
- 在2020年4月至12月期间入院于ICU的严重COVID-19患者队列在出院后的6个月和1年内进行了跟踪.
- 进行了全面的神经心理测试,以评估各种认知领域.
- 进行回归分析以确定医疗和心理因素对认知表现的影响.
主要成果:
- 在1年的随访期间,近一半的患者表现出神经心理测试表现受损.
- 从6个月到1年,在立即回忆,延迟回忆和抑制控制方面观察到显著的改善.
- 虽然医疗变量预测了6个月的认知表现,但焦虑和抑郁症成为长期认知缺陷的重要预测因素.
结论:
- 严重的COVID-19幸存者随着时间的推移表现出普遍的认知改善,特别是在口头记忆和执行功能方面.
- 尽管情况有所改善,但很大一部分患者在出院一年后继续出现认知缺陷.
- 焦虑和抑郁等心理因素对这些患者的长期认知结果起着至关重要的作用.
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