在糖尿病患者中确定与平素相关的牛性尾虫的危险因素

在糖尿病患者中确定与平素相关的牛性尾虫的危险因素

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Dana Shalmon¹, Efrat Bar-Ilan¹, Alon Peled¹

¹Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Acta dermato-venereologica

|April 5, 2024

概括

长期使用类药物 (二基酶4抑制剂) 会增加2型糖尿病患者型皮虫的风险. 阿尔茨海默氏症,痴呆症和某些利尿剂增加了这种风险,西塔格利普丁比林格利普丁或维达格利普丁更受青.

科学领域:

内分泌学在内分泌学.
皮肤病学皮肤病学
药理学药理学是指药理学的学科.

背景情况:

与药物相关的球状皮炎 (BP) 是双基酶4 (DPP-4) 抑制剂治疗的已知的并发症.
识别特定的风险因素对于管理2型糖尿病患者这种不良药物反应至关重要.

研究的目的:

在2型糖尿病患者中识别与平素诱导的型尾虫 (BP) 相关的危险因素.
为了比较不同类型的 Gliptin 中的血压风险,并确定需要谨慎处方的患者子组.

主要方法:

在高等教育中心进行回顾性队列研究 (2008-2021年).
对比了76名T2DM患者与8,060名T2DM患者的GLIPTIN相关血压,而这些患者没有血压,暴露于GLIPTIN.
通过MDClone平台收集的数据,包括人口统计,并发症和药物.

主要成果:

阿尔茨海默病和其他痴呆症在患有高血压的患者中明显更为普遍 (p=0.0013).
同时使用 thiazide 或循环利尿剂与 gliptins 强烈与血压的发展相关 (p<0.0001 两者).
与西塔格利普丁相比,林格利普丁 (OR 5.68) 和维尔格利普丁 (OR 6.61) 与更高的血压风险有关 (p<0.0001对于两者).

结论:

在患有同时存在痴呆症的T2DM患者或长期服用 thiazide/循环利尿剂的患者中, Gliptins 应谨慎处方.
在高风险患者群体中,西塔格利普丁可能是比林格利普丁和维达格利普丁更喜欢的 Gliptin 选择.
需要进一步研究平素相关血压背后的机制.

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