男性染色体多态化对精液质量和IVF/ICSI结果的影响:一项追溯队列研究
Yongjie Lu1,2,3,4,5, Tian Tian1,2,3,4,5, Lixue Chen1,2,3,4,5
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
概括
男性染色体多态性 (MCP) 可以影响体外受精 (IVF) 和细胞内精子注射 (ICSI) 的结果,男性发育明显降低了精子质量,并在某些情况下增加了早产风险.
科学领域:
- 人类遗传学 人类遗传学
- 生殖医学 生殖医学
- 不孕症研究 不孕症研究
背景情况:
- 男性染色体多态 (MCP) 是染色体结构或数量的变化.
- 多种孕产妇对辅助生殖技术 (ART) 结果的影响,包括试管婴儿和ICSI,需要进一步阐明.
- 了解这些影响对于遗传咨询和优化不育夫妇治疗策略至关重要.
研究的目的:
- 研究不同类型的男性染色体多态 (MCP) 对IVF和ICSI治疗结果的影响.
- 为了比较有或没有MCP或MCR的夫妇之间的精液质量,胚胎学和临床结果.
- 确定与ART中不良结果相关的特定MCP.
主要方法:
- 追溯队列研究,对1442对夫妇进行了正常焦化型,1442对夫妇进行了MCP,42对夫妇进行了MCR,42对夫妇进行了MCR和MCP.
- 从北京大学第三医院接受试管婴儿/ICSI的患者收集的数据 (2015-2021年).
- 精液质量,胚胎学和临床结果的比较,按型组分层.
主要成果:
- 对于试管婴儿来说,男性发育与较低的精子活力,渐进的运动性和正常的受精率有关. 男性的9qh+也降低了精子的活力.
- 没有MCPs对IVF的临床结果产生负面影响. 对于ICSI,没有MCP影响精液或胚胎参数,但Yqh+和DGpstk+与早产风险增加相关.
- 在患有MCR的夫妇中,同时存在的MCP显著降低了精子活力和渐进性运动性.
结论:
- 不同的MCP对IVF/ICSI结果具有复杂和异质的影响.
- 男性inv(9) 在试管婴儿中对精子参数和受精率产生不利影响.
- 某些MCP,如Yqh+和DGpstk+,可能与ICSI后早产风险增加有关.
相关概念视频
01:23Infertility in Males
261
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
261
01:41Spermatogenesis
102.4K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.4K
02:19The Y Chromosome Determines Maleness
6.6K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
6.6K
02:32X and Y Chromosomes
25.9K
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
25.9K
03:09Meiosis I
40.6K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
40.6K
01:21Nondisjunction
3.8K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
3.8K