急性胰腺炎与布罗利祖马布诱导的高甘油三血症相关
Faisal Inayat1, Arslan Afzal1, Muhammad Sajeel Anwar2
1Allama Iqbal Medical College, Lahore, Punjab, Pakistan.
概括
布罗利祖马布是一种癌症免疫疗法,很少会导致严重的高甘油三血,导致急性胰腺炎. 在治疗期间监测甘油三水平至关重要,特别是对于患有已有的代谢疾病的患者.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 免疫检查点抑制剂如 pembrolizumab 在癌症治疗中至关重要.
- 布罗利祖马布可以引起与免疫相关的不良事件,包括高甘油三血症.
- 急性胰腺炎是药物诱导的高甘油三血症的罕见但严重并发症.
研究的目的:
- 报告一种罕见的急性胰腺炎病例,该病例是布罗利祖马布诱导的高甘油三血症的次要病例.
- 强调在临床实践中认识到这种罕见的不良事件的重要性.
主要方法:
- 一个非小细胞肺癌患者的病例报告,该患者接受了 pembrolizumab 的治疗.
- 根据修订的亚特兰大分类标准,诊断急性胰腺炎.
- 治疗包括重症监护,液体,疼痛控制,胰岛素输注,最终是三糖的非.
主要成果:
- 患者患有严重的高甘油三血症 (16,901 mg/dL) 和急性胰腺炎.
- 标准治疗是不够的,但甘油三氨酸表导致康复.
- 布罗利祖马布诱导的高甘油三血症被确定为可能的原因.
结论:
- 由于 pembrolizumab 相关的高甘油三血症导致的急性胰腺炎是一种极其罕见的临床实体.
- 意识到这种罕见的不良事件是关键的,因为 pembrolizumab 的使用越来越多.
- 建议在 pembrolizumab 治疗前和治疗期间监测甘油三水平,特别是在具有代谢并发病症的患者中.
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