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逆行式喉功能障碍,一种新的运动障碍:单一中心病例系列和治疗结果
Stijn Arnaert1, Joris Arts2,3, Karlien Raymenants3
1Department of Gastroenterology, AZ Delta, Roeselare, Belgium.
Journal of neurogastroenterology and motility
|April 5, 2024
概括
逆行性喉功能障碍 (R-CPD) 是一种导致无法吐的疾病. 毒素 (BT) 注射提供了显著的症状缓解,超过一半的患者长期经历了持续的改善.
科学领域:
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术创新 在外科创新.
背景情况:
- 逆行性喉功能障碍 (R-CPD) 是一种新发现的临床疾病.
- 症状包括无法吐,,胸部/腹部不适,胀气和浮气.
- 注射肉毒素 (BT) 进入食道上是治疗的一种选择.
研究的目的:
- 报告R-CPD患者的人口统计,症状和治疗结果.
- 评估毒素 (BT) 注射对R-CPD的疗效.
- 评估BT治疗的短期和长期结果.
主要方法:
- 从连续50名R-CPD患者收集前性数据.
- 标准化问卷用于在基线,1个月和随访结束时收集数据.
- 诊断基于一组定义的临床症状.
主要成果:
- 分析了50名患者 (26名女性,平均年龄为27.5岁).
- 超过90%的患者报告说,他们无法吐和发出声.
- 短期:40.8%完全缓解,24.5%很好地改善. 长期 (中位数29个月):51.3%持续完全缓解,12.8%良好改善.
结论:
- 毒素 (BT) 注射显示出对R-CPD的短期和长期有效性.
- 该疗法在大多数患者中提供了非常好的症状改善.
- 结果与之前的发现一致,支持BT作为R-CPD的可行的治疗方法.
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