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Updated: Jun 29, 2025

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在血管系统中通过LNP介导的mRNA输送的生理基础建模

Hamideh Parhiz1, Vladimir V Shuvaev2, Qin Li1

  • 1Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Molecular therapy. Nucleic acids
|April 5, 2024
PubMed
概括

为mRNA-脂质纳米颗粒 (LNP) 开发一种基于生理学的模型有助于预测药物递送和基因表达,弥合RNA治疗的药理动力学-药理动力学差距.

关键词:
MT:交付策略的交付策略药物向的目标是药物.脂质纳米颗粒的使用方法它们是mRNARNA.核酸的输送 核酸的输送药理动力学是药理动力学的一个方面.药物动力学 药物动力学基于生理学的药理动力学.

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