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低TGF-β1血水平与唐氏综合征患者的认知能力下降有关

Margherita Grasso¹, Annamaria Fidilio¹, Francesca L'Episcopo¹

¹Oasi Research Institute-IRCCS, Troina, Italy.

Frontiers in pharmacology

|April 5, 2024

概括

唐氏综合征 (DS) 患者转化生长因子-β1 (TGF-β1) 的低水平与认知能力下降相关. 素可能有助于恢复TGF-β1水平,可能减轻阿尔茨海默氏症在DS中的进展.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
遗传学是一个遗传学.

背景情况:

患有唐氏综合征 (DS) 的人患阿尔茨海默氏病 (AD) 神经病理的风险很高.
在DS中,AD遵循一个临床前阶段,具有可预测的生物标志物变化,需要早期检测方法.
转化生长因子-β1 (TGF-β1),一种抗炎细胞因子,与早期的AD过程有关.

研究的目的:

研究血TGF-β1水平作为唐氏综合征早期认知衰退的潜在生物标志物.
探索TGF-β1,促炎细胞因子和DS的认知状态之间的关系.
评估素对外周血液单核细胞 (PBMCs) 的TGF-β1水平的影响.

主要方法:

一项前性观察性研究,测量了DS患者和健康对照者的血TGF-β1和TNF-α度.
在基线 (T0) 和12个月后期的神经心理评估.
血TGF-β1和PBMCs的活体分析,与DS受试者培养的PBMCs的fluoxetine治疗.

主要成果:

与对照人群相比,在没有AD的年轻和老年DS患者中发现了显著较低的血TGF-β1度.
较低的TGF-β1基线水平与随后的认知能力下降在12个月内有很强的相关性.
在年轻的DS个体中,较低的TGF-β1与高的TNF-α相关;在培养的DS PBMC中,fluoxetine治疗挽救了TGF-β1水平.

结论:

血TGF-β1的降低是唐氏综合征认知能力下降的潜在早期生物标志物.
这些发现表明,TGF-β1减少,炎症和DS的认知障碍之间存在联系.
素在恢复TGF-β1水平方面显示出潜力,为DS患者的认知衰退管理提供了治疗途径.

关键词:

唐氏综合征是什么意思唐氏综合征这就是PBMCs.在TGF-β1中.基于血液的生物标志物认知能力下降认知能力下降

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