系统性审查:患有抑郁症的青少年中的白质微观结构组织
Petya D Radoeva1,2, Victor T Milev3, Jeffrey I Hunt1,2
1Warren Alpert Medical School of Brown University, Providence, Rhode Island.
JAACAP open
|April 5, 2024
概括
患有抑郁症的青少年表现出改变的白质微观结构,特别是在连接关键区域的大脑区域. 这一系统性审查突出了关键白质道中分数异构的差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 抑郁症是青少年的一个重要的心理健康问题.
- 青少年抑郁症背后的神经机制的研究越来越多.
- 白质微观结构在大脑发育和功能中起着至关重要的作用.
研究的目的:
- 在有抑郁症和没有抑郁症的青少年中系统地审查白质微观结构差异.
- 用扩散成像识别青少年抑郁症受影响的特定白质区域.
主要方法:
- 在PubMed和PsycINFO数据库的系统文献搜索.
- 包含原始研究论文,比较患有抑郁症和没有抑郁症的青少年 (11-21岁) 的扩散张力/频谱成像发现.
- 遵守PRISMA指南和PROSPERO注册以进行系统审查.
主要成果:
- 包括14项涉及824名患有抑郁症的青少年和686名对照者的研究.
- 在未切割的带,带,前面的冠状半径,下面的前后带和体中观察到分数异性 (FA) 的显著差异.
- 大多数研究报告了抑郁症青少年的FA降低,表明异常的白质完整性.
结论:
- 患有抑郁症的青少年在边缘-皮层-状体-体膜电路和体中表现出异常的白质微观结构.
- 研究结果表明,在这个年龄组中,与抑郁症相关的脑连接中断与抑郁症有关.
- 未来的研究应该探索青少年抑郁症的发育轨迹,异质性和多式成像集成.
更多相关视频
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.1K
08:42Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
10.6K
相关概念视频
Depression: Overview
242
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
242
Long-term Depression
2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.5K
Depressive Disorders: Etiology
83
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
83
Attention-Deficit/Hyperactivity Disorder
59
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
59
