基于使用深度学习的抗原受体序列识别B细胞子集.
Hyunho Lee1, Kyoungseob Shin1, Yongju Lee1
1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea.
Frontiers in immunology
|April 5, 2024
概括
深度学习模型BCR-SORT从B细胞受体 (BCR) 序列中预测B细胞子集. 这种方法通过降低成本和提高了解免疫反应的数据准确性来增强B细胞研究.
科学领域:
- 免疫学 免疫学 免疫学
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- B细胞受体 (BCR) 定义了抗原特异性,而B细胞子集决定了功能.
- 目前用于识别BCR和B细胞子集的方法需要昂贵的单个细胞隔离,导致信息丢失并限制高通量分析.
- 了解B细胞反应对于疫苗开发和疾病治疗至关重要.
研究的目的:
- 开发一个深度学习模型,BCR-SORT,用于直接从BCR序列预测B细胞子集.
- 为了利用BCR序列内的B细胞激活和成熟特征,准确地预测细胞子集.
- 为B细胞分析提供了物理隔离方法的成本效益和高通量替代方案.
主要方法:
- 开发BCR-SORT,这是一个深度学习模型,利用BCR序列中的B细胞激活和成熟特征.
- 应用BCR-SORT来从BCR序列中预测B细胞子集.
- 通过将其预测与基于物理隔离的方法和先前知识的结果进行比较,验证BCR-SORT的性能.
- 使用BCR-SORT预测的BCR遗传树的重建.
主要成果:
- BCR-SORT从BCR序列准确地预测B细胞子集,利用固有的生物特征.
- 该模型改善了与传统方法相比,BCR遗传树的重建.
- 使用BCR-SORT获得的结果与物理隔离和先前知识的结果一致.
- 对COVID-19疫苗接种者数据的分析揭示了进化轨迹对Omicron结合记忆B细胞的个体间异质性.
结论:
- BCR-SORT为从BCR序列中识别B细胞子集提供了一种强大,具有成本效益和高通量的方法.
- 该模型增强了对B细胞进化轨迹和免疫反应的理解.
- BCR-SORT具有很大的潜力,可以促进免疫学研究,特别是在疫苗开发和传染病研究方面.
相关概念视频
Diversity of Antigen Receptors
582
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
582
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Special Features of Adaptive Immunity
810
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
810
T Cell Activation and Clonal Selection
721
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
721


