在患有结核病的儿童和青少年中,QuantiFERON-TB的逆转
Paula Rodríguez-Molino1,2,3,4, Araceli González Sánchez5, Antoni Noguera-Julián6,7,8,9
1General Pediatrics, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain.
Frontiers in immunology
|April 5, 2024
概括
量子费隆-结核病 (QFT) 试验逆转发生在16.9%的患有结核病感染的儿童中. 较年轻的儿童和具有较小TST强度的儿童表现出更高的QFT逆转率.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 在儿童中,结核病 (TB) 感染的诊断通常依赖于免疫学测试.
- 广为使用的QuantiFERON-TB Gold In-Tube (QFT) 试验,但其在儿科群体中的稳定性和逆转模式需要进一步调查.
研究的目的:
- 分析诊断出结核病或结核感染的儿童中的QuantiFERON-TB (QFT) 试验逆转率和模式.
- 在这个儿科队列中确定与QFT逆转相关的因素.
主要方法:
- 对136名确诊患有结核病或结核感染的儿童进行了回顾性分析,QFT测定结果呈阳性.
- 随访时间从0.4年到11年不等 (中位数为21个月).
- 在回归者和非回归者之间比较QFT测定结果 (TB1和TB2水平) 和相关的临床因素.
主要成果:
- 在研究的儿童中,在16.9%的儿童中观察到QFT测定逆转.
- 与非逆转患者相比,逆转患者的TB1和TB2水平显著下降 (分别为p=0.001和p=0.005).
- 在5岁以下的儿童 (25.0%) 和结核素皮肤测试 (TST) 强度<15mm (29%) 的儿童中发现更高的逆转率.
结论:
- 虽然QuantiFERON-TB测定在患有结核病的儿童中通常保持阳性,但逆转是显著的现象,约有16%的病例发生.
- QFT逆转似乎遵循一个渐进而稳定的模式.
- 年轻的年龄和较小的TST强化是儿童QFT试验逆转的显著预测因素.
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