脊髓损伤干细胞移植的现状和未来前景
Edoardo Agosti1, Marco Zeppieri2, Andrea Pagnoni1
1Division of Neu rosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia 25123, Italy.
World journal of transplantation
|April 5, 2024
概括
脊髓损伤 (SCI) 的干细胞治疗显示出希望,一些患者经历了功能和感官改善. 然而,在广泛临床使用之前,需要进一步研究以优化治疗方法并解决安全问题.
科学领域:
- 再生医学是一种再生医学.
- 神经科学是一个神经科学.
- 临床试验 临床试验
背景情况:
- 之前对脊髓损伤 (SCI) 的干细胞治疗评估面临挑战.
- 当前的研究经常在早期试验中优先考虑安全性,忽视有效性和翻译可行性.
- 这种差距需要对SCI的干细胞治疗临床准备情况进行评估.
研究的目的:
- 系统地审查和分析涉及脊髓损伤 (SCI) 干细胞治疗的临床试验结果.
- 提供有关干细胞在SCI治疗中的应用现状的最新概述.
主要方法:
- 在PubMed,Embase,RCA和Cochrane图书馆进行了系统的文献搜索,直到2023年10月.
- 关键词包括"脊髓"",损伤"",临床试验"",干细胞"",功能结果"和"不良事件".
- 包括的研究是随机对照试验和关于SCI干细胞治疗的非随机对照试验.
主要成果:
- 该审查分析了236项符合条件的研究,涉及1086名患有SCI的患者,主要是宫损伤.
- 骨髓干细胞是最常见的 (71.1%),在32.7%至40.8%的患者中观察到AIS得分的功能改善,30.9%的患者有感官改善.
- 不良事件很少发生,包括发烧 (15.1%),头痛 (4.3%) 和头 (2.6%).
结论:
- 基于干细胞的疗法显示出SCI治疗的潜力,其功能和感官改善证明了这一点.
- 限制和潜在的不良事件需要仔细优化移植参数.
- 在临床采用之前,对SCI病理生理学,伦理考虑和安全性 (瘤性,免疫性) 的进一步研究至关重要.
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