疾病负担和急性过敏反应的未满足需求 - 从患者的角度来看
Emelie Andersson1, Sofia Löfvendahl1, Sara Olofsson1
1The Swedish Institute for Health Economics (IHE), Lund, Sweden.
The World Allergy Organization journal
|April 5, 2024
概括
患有中度至重度急性过敏反应 (AAR) 的患者经历了显著的日常生活中断和焦虑,即使没有过敏反应. 对许多人来说,获得和使用药物对许多人来说都是一个挑战,这凸显了对过敏治疗的大量未满足需求.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 临床研究 临床研究
- 患者报告的结果
背景情况:
- 急性过敏反应 (AAR) 的严重程度不同,系统性皮质类固醇 (CS) 用于中度至严重的病例.
- 对于那些有过敏反应的风险的人来说,建议使用上腺素自注射器,但对非过敏反应性AAR的研究是有限的.
- 这项研究侧重于中度至重度AAR患者的自我报告疾病负担.
研究的目的:
- 用CS治疗的患者样本具有中度至重度AAR史的特征.
- 评估自我报告的疾病负担,包括日常生活的影响,焦虑和治疗障碍.
主要方法:
- 一项调查研究与成年人进行了调查,这些成年人经历了用CS治疗的AAR.
- 参与者通过网络小组和社交媒体招募.
- 一个问卷评估过敏史,AAR经验和疾病负担.
主要成果:
- 这项研究包括387名参与者 (80%为女性,平均年龄为41岁);33%的人被处方上腺素.
- 常见症状包括呼吸道 (80%) 和皮肤 (78%) 症状;平均AAR严重程度为6.1/10.
- 超过80%的人经历了干扰日常活动的AAR,50%的人面临着工作/学习或休的限制,大多数人报告了焦虑,其中43%的人担心自己的生命. 还报告了药物治疗 (66%) 和吞困难 (26%) 的情况. 与未服用上腺素的患者相比,服用上腺素的患者有更严重的AAR,但与不服用上腺素的患者相比,焦虑和日常生活的影响相似.
结论:
- 接受CS治疗的中度至重度AAR患者经历了重大疾病负担,包括焦虑和日常生活中断.
- 药物获取和管理方面的挑战是普遍存在的.
- 即使在没有上腺素处方的患者中,也存在相当大的疾病负担,这强调需要更好地了解和管理超出过敏反应之外的AAR.
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