在两个秘鲁医院,怀孕期间的结核病和新生儿不良后果
Noelia V Garay-Aguilar1, Lizbeth R Reynoso-Rosales1, Anita P Llamo-Vilcherrez2,3
1Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
概括
怀孕期间结核病 (TB) 显著增加了新生儿不良后果的风险. 患有结核病的孕妇有超过3.5倍的新生儿出生时体重低,早产或为妊娠年龄小的可能性.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 新生儿科学 新生儿科学
背景情况:
- 结核病 (TB) 是全球主要的死亡原因,在怀孕期间由于症状与生理变化重叠而造成诊断挑战.
- 孕妇未经诊断或未经治疗的结核病可能会导致严重的孕产妇-产周并发症.
研究的目的:
- 调查孕妇肺结核 (TB) 与新生儿不良结果之间的关联.
- 在孕产妇结核病的背景下,量化特定新生儿并发症的风险.
主要方法:
- 进行了一项回顾性队列研究,涉及在秘鲁利马的两家公共医院分娩的孕妇.
- 评估的新生儿不良结果包括早产,低出生体重 (LBW) 和对于妊娠年龄来说小 (SGA).
- 计算了95%置信区间的原始和调整的相对风险,以确定关联.
主要成果:
- 该研究分析了212名患者的数据,48.1%的患者在怀孕期间被诊断出结核病.
- 显著比例的新生儿 (23.1%) 经历了至少一个不良结果:8%的LBW,11.3%的早产和12.3%的SGA.
- 在调整后,患有肺结核的孕妇患有新生儿不良后果的风险增加了3.52倍 (aRR: 3.52; 95%CI: 1.93-6.68).
结论:
- 怀孕期间的肺结核是独立和联合与新生儿不良结果相关的.
- 这些结果包括低出生体重,早产,以及对妊娠年龄来说小.
- 这些发现强调了对孕妇结核病查和管理的急需,以改善新生儿健康.
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