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相关概念视频

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K

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Updated: Jun 29, 2025

Isolation of Human Mesenchymal Stem Cells and their Cultivation on the Porous Bone Matrix
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高葡萄糖的微环境和人类介质干细胞的行为.

Muhammad Abdul Mateen1, Nouralsalhin Alaagib1, Khawaja Husnain Haider2

  • 1Basic Sciences, Sulaiman AlRajhi University, AlQaseem 52736, Saudi Arabia.

World journal of stem cells
|April 5, 2024
PubMed
概括

高葡萄糖通过破坏信号通路和线粒体功能,对介质干细胞 (MSC) 产生负面影响,导致生存率降低. 恢复线粒体膜潜力 (MtMP) 可能改善糖尿病患者的MSC功能.

科学领域:

  • 生物医学科学 生物医学科学
  • 细胞生物学 细胞生物学
  • 代谢研究研究 代谢研究

背景情况:

  • 高葡萄糖 (HG) 条件和高血糖会损害介酶干细胞 (MSC) 的生存和功能.
  • 这种损伤涉及到猛素 (mTOR) -酸酸3-激酶 (PI3K) -Akt信号通路的哺乳动物标的调节失调.
  • 细胞功能障碍由线粒体功能障碍加剧,包括缺陷的线粒体膜潜力 (MtMP) 和减少的ATP产生.
关键词:
脂肪组织的脂肪组织.细胞灭亡 (apoptosis) 是一种死亡的过程.生物能源学 生物能源学细胞存活率 细胞存活率细胞疗法是一种细胞疗法.过高血糖症的发生.介质细胞干细胞 介质细胞干细胞线粒体中的线粒体.干细胞是一种干细胞.

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