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介酶干细胞如何转化为脂肪细胞:对当前对脂肪原分化的理解概述

Shan-Shan Liu¹, Xiang Fang², Xin Wen¹

¹Department of Reumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, Jiangsu Province, China.

World journal of stem cells

|April 5, 2024

概括

介酶干细胞 (MSCs) 通过精确的步骤分化为脂肪细胞. 本综述探讨了分子机制,包括信号通路和表观遗传学,控制这一关键的脂肪生成过程.

科学领域:

细胞生物学细胞生物学
分子生物学分子生物学
生物化学生物化学

背景情况:

介质细胞干细胞 (MSCs) 是能够自我更新和分化的多能细胞.
脂肪生成,MSCs分化为脂肪细胞 (脂肪细胞) 的过程,对代谢健康至关重要.
像C/EBPα和PPARγ这样的关键转录因子是已知的脂肪生成调节者.

研究的目的:

审查当前关于MSCs脂肪生成差异化机制的知识.
要突出信号通路,非编码RNA和表观遗传修饰在MSC脂肪生成中的作用.
讨论异常脂肪生成与疾病发展之间的联系.

主要方法:

对MSC脂肪生成现有研究的文献综述.
专注于分子机制,包括信号通路,非编码RNA和表观遗传学 (DNA甲基化和乙化).
讨论脂肪生成在疾病中的影响.

主要成果:

脂肪生成是一个多步骤的过程,涉及精确控制MSC承诺和成熟.
信号通路,非编码RNA和表观遗传因素显著影响脂原体的分化.
脂肪生成的失调与各种疾病有关.

结论:

对MSC脂肪生成的全面理解需要整合信号,非编码RNA和表观遗传学的知识.
对这些机制的进一步研究可以提供有关代谢疾病的见解.
本次审查巩固了目前的理解,并确定了未来调查的领域.

关键词:

亚原体的分化差异化表观遗传调节表观遗传调节介质细胞干细胞介质细胞干细胞.没有编码的RNA.信号通道的信号通道.

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相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...