在结核性脑膜炎的急性缺血性中风
Yi-Jia Guo1,2,3, Xin-Ling Gan4, Ru-Yun Zhang5
1Beijing Chest Hospital, Capital Medical University, Beijing, China.
Frontiers in public health
|April 5, 2024
概括
结核性脑膜炎 (TBM) 中的急性缺血性中风 (AIS) 是由炎症标志物预测的. 在TBM患者中,AIS部分调解了炎症与长期功能结果之间的联系.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 血管医学 血管医学
背景情况:
- 在结核性脑膜炎 (TBM) 中中风的机制尚不清楚.
- 急性缺血性中风 (AIS) 是TBM患者的一种重大并发症.
- 确定AIS的预测因素及其在功能障碍中的作用至关重要.
研究的目的:
- 在TBM患者中调查AIS的预测因子.
- 确定AIS是否介导着炎症标志物与90天后功能障碍之间的关系.
主要方法:
- 在五家医院观察了1353名TBM患者的队列.
- 一般化的线性混合模型和子组分析确定了AIS预测因素.
- 调解分析探讨了AIS在与炎症相关的功能结果中的作用.
主要成果:
- 入院后30天内AIS的发生率为20.4%.
- 预测AIS的预测因素包括年龄≥35,高血压,糖尿病,吸烟,脑膜增强和脑水.
- AIS调解了脑膜增强和功能障碍之间的联系的16.98%.
结论:
- 神经成像炎症标志物是TBM中AIS的显著预测因素.
- 在炎症和功能结果之间的关系中,AIS发挥了部分调解作用.
- 向炎症和脑水可能会改善TBM患者的功能结果.
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