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两性,酸合的多基纳米状系统,用于高效的glipizide输送

Vipan Kumar^1,2, Neelam Poonia³, Pradeep Kumar⁴

¹Department of Pharmaceutical Chemistry, JCDM College of Pharmacy, Sirsa 125055, India.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

|April 5, 2024

概括

装有glipizide的新纳米细胞为2型糖尿病管理提供持续释放. 这种创新的配方在没有毒性的老鼠中显示出显著的血糖降低,为传统治疗提供了一个有希望的替代方案.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

格利皮齐德 (glipizide) 是一种硫基尿素,可以治疗2型糖尿病,但需要经常服用.
持续释放纳米配方比传统抗糖尿病药物具有潜在的优势.
口服活性药物输送系统对于改善患者的服药性和治疗结果至关重要.

研究的目的:

开发和描述口服活跃的持续释放纳米细胞,用于平的输送.
在糖尿病老鼠模型中评估新型纳米配方的疗效和安全性.
探索酸结合F127 (LAF127) 阻断共聚合物的药物输送应用中的潜力.

主要方法:

合成和特征的两性LAF127块共聚物.
使用薄膜水化技术制备带有glipizide的纳米粒 (GNM).
评估颗粒大小,多分散性指数 (PDI),表面电荷,体外药物释放,体内抗糖尿病活性和毒性.

主要成果:

优化GNM的粒子大小为341.40 ± 3.21 nm,PDI<0.2,表面电荷为-17.11 ± 6.23 mV.
试验室研究表明,glipizide从纳米细胞中持续释放的特征.
在体内研究显示,糖尿病大鼠的血糖水平在长达24小时内显著降低,没有观察到毒性.

结论:

合成的LAF127块共聚合物适合开发有效的口服持续释放纳米细胞.
含有glipizide的纳米粒显示出对2型糖尿病的治疗潜力有很大的希望.
开发的纳米配方提供了一个安全有效的替代传统的glipizide管理.

关键词:

两两的两两的格利皮齐德的使用方法 LAF127共聚合物合成的方法纳米微粒是一种微小的微粒.口服药物递送系统是指口服药物递送系统.在Pluronic F127中使用.链条毒素 (Streptozotocin) 是一种毒素.

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