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Updated: Jun 29, 2025

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肝细胞癌免疫微环境和检查点抑制剂-当前状态

Tarana Gupta¹, Nikhil Sai Jarpula²

¹Division of Hepatology, Department of Medicine, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak 124001, Haryana, India. taranagupta@gmail.com.

World journal of hepatology

|April 5, 2024

概括

肝细胞癌 (HCC) 治疗正在改善. 将局部治疗与免疫检查点抑制剂相结合,可提高晚期肝癌患者的免疫治疗反应和存活率.

科学领域:

肝病学肝病学是一种肝病学.
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

肝细胞癌 (HCC) 是一种主要的肝脏瘤,死亡率高.
巴塞罗那诊所肝癌分期系统指导治疗决策.
瘤微环境 (TME) 概念为HCC免疫性提供了新的见解.

研究的目的:

探索HCC的免疫性及其对治疗的影响.
审查TME在HCC中的作用及其对免疫治疗的反应.
评估先进的HCC新兴组合疗法.

主要方法:

关于HCC,TME和免疫治疗的当前文献的综述.
对与病毒相关的HCC免疫性数据的分析.
对结合局部治疗与免疫检查点抑制剂 (ICI) 的研究进行评估.

主要成果:

与病毒相关的HCC表现出更高的免疫性,细胞毒性T淋巴细胞增加和调节性T细胞减少.
免疫性TME预测免疫疗法,特别是ICI的更好的反应.
地方区域疗法和ICI的组合疗法显示,在不可切除或晚期HCC中,存活率有所改善.

结论:

TME显著影响HCC免疫性和治疗反应.
调节TME以提高免疫性是一种有前途的治疗策略.
将局部治疗与ICI结合起来,可以为高级HCC患者提供更好的结果.

关键词:

在Atezolizumab中使用.贝瓦西祖马布 (bevacizumab) 是一种药物.肝细胞癌是肝细胞癌.免疫检查点抑制剂免疫检查点抑制剂这就是Pembrolizumab.瘤的免疫微环境

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