快速生长与脂质特征之间的关联:系统性审查和元分析
Botian Chen1, Yunli Chen2, Yuyang Wang1
1School of Public Health, Peking University Health Science Center, Beijing, China.
Frontiers in endocrinology
|April 5, 2024
概括
儿童的快速生长与较低的高密度脂蛋白胆固醇 (HDL-C) 有关,但与其他脂质无关. 诸如生长时间和国家发展等因素影响了这些脂质特征变化.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢性疾病研究研究.
- 营养科学 营养科学
背景情况:
- 在全球范围内,代谢性疾病的患病率不断增加.
- 脱脂症和代谢性疾病之间存在强烈的关联.
- 婴儿和儿童快速生长和脂质失调之间有争议的联系.
研究的目的:
- 调查出生后快速生长的和没有出生后快速生长的个体的脂质特征.
- 确定影响快速生长-脱脂症关系的混因素.
主要方法:
- 对11项涉及1148名参与者的研究进行了系统的元分析.
- 在Medline,EMBASE,CNKI和WANFANG数据库中进行了搜索.
- 使用漏斗图和埃格尔/贝格测试评估的出版偏差.
主要成果:
- 快速增长与HDL-C负相关 (WMD=-0.068).
- 对于甘油三 (TG),总胆固醇 (TC) 或总体的LDL-C,没有发现显著的关联.
- 分层分析显示,根据国家的发展,年龄,出生体重和SGA状态,TG,TC和LDL-C的相关性各不相同.
结论:
- 快速生长会影响脂质特征,特别是在幼儿时期.
- 增长时间,国家发展水平和出生体重是影响因素的关键因素.
- 研究结果为预防代谢性疾病的策略提供了信息.
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