血液中含量与成人的骨矿物质密度之间的关系:一个横截面研究
Yi Lei1,2,3, Meiqian Guo1,2,3, Juan Xie1,2,3
1Department of Nephrology, The Affiliated Huai'an Hospital of Xuzhou Medical University and Huai'an Second People's Hospital, Huai'an, China.
Frontiers in endocrinology
|April 5, 2024
概括
血中含量升高与美国成年人骨矿物质密度 (BMD) 降低有关. 这种关联在糖尿病或慢性病患者中特别强烈,突出的是.
科学领域:
- 环境健康 环境健康
- 骨的新陈代谢 骨的新陈代谢
- 毒理学 毒理学 毒理学
背景情况:
- 骨质疏松症的患病率随着年龄的增长而增加,造成了重大的社会经济负担.
- 接触重金属,特别是,越来越多地被认为对骨健康有不利影响.
- 了解暴露与骨矿物质密度之间的关系对于公共卫生至关重要.
研究的目的:
- 研究美国成年人血液中含量与骨矿物质密度 (BMD) 之间的关联.
- 探索这种关联在不同的人口和临床子组中如何变化.
主要方法:
- 利用了2013-2014年和2017-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用加权多重回归,通用加权建模和光滑曲线拟合来分析血液中的和大腿骨的BMD.
- 根据年龄,性别,种族,慢性病和糖尿病进行了分组分析.
主要成果:
- 在多个大腿部部位 (全大腿,大腿部部,三角骨) 血中含量和BMD之间观察到显著的负相关性.
- 和BMD之间的负面关联在女性,非西班牙裔白人,其他西班牙裔个人以及患有慢性病或糖尿病的人群中更为明显.
- 血液中的对骨矿物质密度的影响最大的是糖尿病和慢性病的参与者.
结论:
- 在美国成年人中,血液中的含量与骨矿物质密度之间存在显著的负相关性.
- 这些发现强调了暴露对骨的潜在毒性.
- 强调需要针对高风险人群进行有针对性的干预,例如糖尿病或慢性病患者.
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