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核糖体蛋白L22像1:肺腺癌的一个有前途的生物标志物

Yahua Wu¹, Na Yao¹, Bin Du¹

¹Department of Medical Oncology, Fujian Medical University Union Hospital, No. 29 Xinquan Street, Fuzhou, 350000, Fujian, China.

Journal of Cancer

|April 5, 2024

概括

核糖体蛋白L22像1 (RPL22L1) 在肺腺癌 (LUAD) 中升高,并与较差的患者结局有关. 这表明RPL22L1可以作为LUAD预后的新生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

肺腺癌 (LUAD) 是全球癌症死亡的主要原因之一.
在LUAD中,核糖体蛋白L22像1 (RPL22L1) 的作用在很大程度上仍未被探索.
识别新的预后生物标志物对于改善LUAD患者管理至关重要.

研究的目的:

系统地研究RPL22L1在LUAD中的表达,甲基化,预后价值和潜在功能.
在LUAD中探索RPL22L1与瘤免疫微环境 (TME) 之间的关联.

主要方法:

公共数据库的生物信息分析 (TCGA,GEO,TIMER,UALCAN,GSCA,MethSurv).这些数据库的使用方法是:
使用免疫组织化学 (IHC) 验证RPL22L1表达.
免疫细胞透 (ssGSEA, TIMER, TISCH) 和基因组丰富的分析.

主要成果:

与正常组织相比,RPL22L1在LUAD组织中显著上调,由IHC证实.
高RPL22L1表达与LUAD患者的预后不佳相关,是独立的预后因素.
过度表达RPL22L1与低甲基化有关,特定的CpG与预后有关.
RPL22L1涉及细胞循环调节和信号通路 (MYC目标,E2F目标,mTORC1).
RPL22L1表达与免疫细胞透和TME中的免疫分数负相关.

结论:

RPL22L1是肺腺癌的一个有前途的诊断和预后生物标志物.
RPL22L1可能通过细胞循环调节和瘤免疫微环境的调节来影响LUAD进展.

关键词:

生物标志物生物标志物肺部腺癌瘤是肺部腺癌.预测预后预测预测在RPL22L1中使用.在TME中,它是最重要的.

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